Versatile nitrilases: Nitrile-hydrolysing enzymes
نویسندگان
چکیده
منابع مشابه
Nitrilases – an Attractive Nitrile Degrading Biocatalyst
Nitrile compounds are found everywhere in nature. They are synthesized naturally as well as xenobiotically. Nitrilases are nitrile degrading enzymes and belong to nitrilase superfamily. They convert nitriles into corresponding acids in a single step pathway. Members of this superfamily are present in both prokaryotes and eukaryotes and have characteristics αββα fold. They pose conserved Cystein...
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Over the past decades, nitrilases have drawn considerable attention because of their application in nitrile degradation as prominent biocatalysts. Nitrilases are derived from bacteria, filamentous fungi, yeasts, and plants. In-depth investigations on their natural sources function mechanisms, enzyme structure, screening pathways, and biocatalytic properties have been conducted. Moreover, the im...
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The most recent developments in the use of hydrolytic enzymes proteases, lipases and nitrilases are summarized: Sterically demanding a,a-disubstituted carboxylic esters can be enzymatically resolved using a commercially available protease derived from Aspergillus oryzae. A significant enhancement of selectivity and activity of Candida cylindracea lipase in irreversible acyl transfer reactions m...
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The salivary glands of adult blowflies (Calliphora erythrocephala) contain enzymes that hydrolyse phosphatidylinositol, predominantly by a Ca2+-independent deacylation, though a Ca2+-dependent phosphodiesterase (phospholipase C) activity could be detected. The deacylating enzymes could also hydrolyse phosphatidylcholine and phosphatidylethanolamine, and were secreted in the saliva. Homogenizati...
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Paclitaxel (taxol) is an antimicrotubule agent widely used in the treatment of cancer. Taxol is prepared in a semisynthetic route by coupling the N-benzoyl-(2R,3S)-3-phenylisoserine sidechain to the baccatin III core structure. Precursors of the taxol sidechain have previously been prepared in chemoenzymatic approaches using acylases, lipases, and reductases, mostly featuring the enantioselecti...
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ژورنال
عنوان ژورنال: FEMS Microbiology Letters
سال: 1994
ISSN: 0378-1097,1574-6968
DOI: 10.1111/j.1574-6968.1994.tb07036.x